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Jonathan Yang, MD, PhD

Associate Professor


Dr. Yang is the Director of Metastatic Disease and Developmental Therapeutics in the Department of Radiation Oncology at the University of Washington. Dr. Yang specializes in treating metastatic cancer and central nervous system malignancies with advanced radiation techniques including stereotactic radiation therapy and proton therapy, as well as novel and cutting-edge clinical trials.

Patient Care Philosophy

I believe in understanding the specific needs of patients and providing care that is consistent with their goals. As the complexity of cancer treatments evolves, I am an advocate for my patients. I want patients to feel that, yes we are dealing with a difficult diagnosis, but there are options, and I am here for them and am privileged to be on their team.

Education and Training

College: University of North Carolina-Chapel Hill

Medical Education: Yale University

Doctorate: Vrije Universiteit-Amsterdam

Internship: Memorial Sloan Kettering Cancer Center

Residency: Memorial Sloan Kettering Cancer Center

Selected Publications: (total: 85)

  1. Yang, JT, Wijetunga NA, Pentsova E, Wolden S, Young R, Correa D, Zhang Z, Zheng J, Steckler A, Bucwinska W, Bernstein A, Betof-Warner A, Yu H, Kris MG, Seidman A, Wilcox J, Malani R, Lin Andrew, DeAngelis LM, Lee N, Powell SN, Boire A. Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients with Solid Tumor Leptomeningeal Metastasis. Journal of Clinical Oncology Epub 7/8/2022. PMID: 35802549
  2. Wijetunga NA, Boire A, Young R, Yamada Y, Wolden S, Yu H, Kris M, Seidman AD, Betof-Warner A, Diaz M, Reiner A, Malani R, Pentsova E, Yang JT. Quantitative Cerebrospinal Fluid Circulating Tumor Cells are a Potential Biomarker of Response for Proton Craniospinal Irradiation for Leptomeningeal Metastasis. Neurooncology Advances 3(1):vdab181 (2022). PMID: 34993483
  3. Mathis NJ, Doyle CJ, Rosen DB, Wijetunga NA, Vaynrub M, Bartelstein M, Guttmann DM, Brennan VS, Yamada YJ, Gillespie EF, Yerramilli D, Yang JT. Personalized Treatment Selection Leads to Low Rates of Local Salvage Therapy for Bone Metastases. International Journal of Radiation Oncology Biology Physics 112(1):99-105 (2022). PMID: 34715255
  4. Wijetunga NA, dos Anjos CH, Zhi I, Robson M, Tsai CJ, Yamada Y, Dover Laura, Gillespie E, Xu AJ, Yang JT. Long-term Disease Control and Survival Observed after Stereotactic Ablative Body Radiotherapy for Oligometastatic Breast Cancer. Cancer Medicine 10(15):5163-5174 (2021). PMID: 34159748
  5. Tsai CJ, Gomez DR, Yang TJ. Metastatic Disease as a Distinct Discipline in Radiation Oncology. JAMA Oncology 7(1):21-22 (2021). PMID: 33057693
  6. Yang TJ, Wijetunga NA, Yamada J, Wolden S, Mehallow M, Goldman DA, Zhang Z, Young RJ, Kris MG, Yu HA, Gavrilovic IT, Lin A, Santomasso B, Grommes C, Piotrowski AF, Schaff L, Stone JB, DeAngelis LM, Boire A, Pentsova E. Clinical Trial of Proton Craniospinal Irradiation for Leptomeningeal Metastases. Neuro Oncology 23(1):134-143 (2021). PMID: 32592583
  7. Lockney A, Wang D, Pei X, Goldman D, Zhang Z, Lin A, Chan TA, Yamada Y, Beal K, Yang TJ. Phosphatidylinositol-3-kinase Mutations are Associated with Increased Local Failure in Brain Metastases Treated with Radiation. International Journal of Radiation Oncology*Biology*Physics 101(4):833-844 (2018). PMID: 29976496
  8. Sperduto PW, Yang TJ, Beal K, Pan H, Brown PD, Bangdiwala A, Shanley R, Yeh N, Gaspar LE, Braunstein S, Sneed P, Boyle J, Kirkpatrick JP, Mak K, Shih HA, Engleman A, Roberge D, Arvold ND, Alexander B, Awad MM, Contessa J, Chiang V, Hardie J, Ma D, Lou M, Sperduto W, Mehta M. Estimating Survival in Patients with Lung Cancer and Brain Metastases- An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA). JAMA Oncology 3(6):827-831 (2017). PMID: 27892978
  9. Magnuson W, Lester-Coll NH, Wu AJ, Yang TJ, Lockney NA, Beal K, Amini A, Patil T, Kavanagh BD, Camidge DR, Braunstein SE, Boreta LC, Balasubramanian S, Ahluwalia MS, Rana NG, Attia A, Gettinger SN, Contessa JN, Yu JB, Chiang VL. Management of Brain Metastases in TKI-naïve Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer: A Multi-Institutional Analysis. Journal of Clinical Oncology 35(10):1070-1077 (2017). PMID: 28113019
  10. Brennan C*, Yang TJ*, Hilden P, Zhang Z, Chan K, Yamada Y, Chan TA, Lymberis SC, Narayana A, Tabar V, Gutin PH, Ballangrud A, Lis E, Beal K. A Phase 2 Trial of Stereotactic Radiosurgery Boost After Surgical Resection for Brain Metastases. International Journal of Radiation Oncology*Biology*Physics 88(1):130-6 (2014). *Co-first Authors. PMID: 24331659