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Clinical Research

For some patients, taking part in a clinical trial may be the best treatment choice. Clinical trials are part of the cancer research process. Clinical trials are done to find out if new cancer treatments are safe and effective or better than the standard treatment.  Many of today’s standard treatments for cancer are based on earlier clinical trials. Patients who take part in a clinical trial may receive the standard treatment or be among the first to receive a new treatment. Patients who take part in clinical trials also help improve the way cancer will be treated in the future. Even when clinical trials do not lead to effective new treatments, they often answer important questions and help move research forward.

Brain and Spine Tumors

NCT02179086

Randomized Phase II Trial of Hypofractionated Dose-Escalated Photon IMRT or Proton Beam Therapy Versus Conventional Photon Irradiation with Concomitant and Adjuvant Temozolomide in Patients with Newly Diagnosed Glioblastoma

Read More at ClinicalTrials.gov

Investigators: Lia Halasz, M.D.

NCT01898494

Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer

Read More at ClinicalTrials.gov

Breast Cancer

NCT01901094

Alliance A011202: A Randomized Phase III Trial Comparing Axillary Lymph Node Dissection to Axillary Radiation in Breast Cancer Patients (cT1-3 N1) who have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy

Read More at ClinicalTrials.gov

Investigators: Janice Kim, M.D.

NCT01872975

A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chest Wall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy

Read More at ClinicalTrials.gov

Investigators: Janice Kim, M.D.

Gastrointestinal Cancers

NCT02008656

A Phase II Multicenter Randomized Trial Evaluating 3-year Disease-Free Survival in Patients with Locally Advanced Rectal Cancer treated with Chemoradiation plus Induction or Consolidation Chemotherapy, and Total Mesorectal Excision or Non-Operative Management

Read More at ClinicalTrials.gov

NCT01515787

A Phase II/III trial of Neoadjuvant FOLFOX, with Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection with Total Mesorectal Excision

Read More at ClinicalTrials.gov

Genitourinary Cancers

Gynecologic Cancers

NCT00980954

Phase III Randomized Study of Concurrent Chemotherapy and Pelvic Radiation Therapy with or Without Adjuvant Chemotherapy in High-Risk Patients with Early-Stage Cervical Carcinoma Following Radical Hysterectomy 

Read More at ClinicalTrials.gov

NCT00942357

A Randomized Phase III Trial of Cisplatin and Tumor Volume Directional Irradiation Followed By Carboplatin and Paclitaxel Vs. Carboplatin and Paclitaxel for Optimally Debulked, Advanced Endometrial Carcinoma

Read More at ClinicalTrials.gov

NCT01101451

A Randomized Phase III Clinical Trial of Adjuvant Radiation Versus Chemoradiation in Intermediate Risk, Stage I/IIA , Cervical Cancer Treated with Initial Radical Hysterectomy and Pelvic Lymphadenectomy

Read More at ClinicalTrials.gov

Head and Neck Cancers

NCT01810913

Randomized Phase II/III Trial of Surgery and Postoperative Radiation Delivered with Concurrent Cisplatin versus Docetaxel versus Docetaxel and Cetuximab for High-Risk Squamous Cell Cancer of the Head and Neck

Read More at ClinicalTrials.gov

Lung and Thoracic Cancers

Lymphomas/Leukemia

Pediatric/Childhood Tumors

NCT00085735

A Study Evaluating Limited Target Volume Boost Irradiation and Reduced Dose Craniospinal Radiotherapy (18.00 Gy) and Chemotherapy in Children with Newly Diagnosed Standard Risk Medulloblastoma: A Phase III Double Randomized Trial

Read More at ClinicalTrials.gov

NCT02180867

Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery

Read More at ClinicalTrials.gov

Sarcomas

Skin Cancer/Melanoma

Other