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Stephen Bowen, PhD

Associate Professor

Education and Training

College: University of California, Los Angeles, CA

Graduate School: University of Wisconsin School of Medicine and Public Health, Madison, WI

Selected Publications

Comparison of regional lung perfusion response on longitudinal MAA SPECT/CT in lung cancer patients treated with and without functional tissue-avoidance radiation therapy. Thomas HMT, Zeng J, Lee HJ Jr, Sasidharan BK, Kinahan PE, Miyaoka RS, Vesselle HJ, Rengan R, Bowen SR.
Br J Radiol. 2019 Aug 12:20190174. doi: 10.1259/bjr.20190174. [Epub ahead of print] PMID: 31364397

Voxel Forecast for Precision Oncology: Predicting Spatially Variant and Multiscale Cancer Therapy Response on Longitudinal Quantitative Molecular Imaging. Bowen SR, Hippe DS, Chaovalitwongse WA, Duan C, Thammasorn P, Liu X, Miyaoka RS, Vesselle HJ, Kinahan PE, Rengan R, Zeng J.
Clin Cancer Res. 2019 Aug 15;25(16):5027-5037. doi: 10.1158/1078-0432.CCR-18-3908. Epub 2019 May 29. PMID: 31142507

Functional Liver Imaging and Dosimetry to Predict Hepatotoxicity Risk in Cirrhotic Patients With Primary Liver Cancer. Schaub SK, Apisarnthanarax S, Price RG, Nyflot MJ, Chapman TR, Matesan M, Vesselle HJ, Bowen SR. Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):1339-1348. doi: 10.1016/j.ijrobp.2018.08.029. Epub 2018 Aug 28. PMID:30170100

Correlation of Functional Lung Heterogeneity and Dosimetry to Radiation Pneumonitis using Perfusion SPECT/CT and FDG PET/CT Imaging.
Lee HJ Jr, Zeng J, Vesselle HJ, Patel SA, Rengan R, Bowen SR. Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):1255-1264. doi: 10.1016/j.ijrobp.2018.05.051. Epub 2018 Jun 1. PMID: 30108002

Regional Radiation Dose-Response Modeling of Functional Liver in Hepatocellular Carcinoma Patients With Longitudinal Sulfur Colloid SPECT/CT: A Proof of Concept. Price RG, Apisarnthanarax S, Schaub SK, Nyflot MJ, Chapman TR, Matesan M, Vesselle HJ, Bowen SR. Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):1349-1356. doi: 10.1016/j.ijrobp.2018.06.017. Epub 2018 Jun 19. PMID: 29932945

Tumor radiomic heterogeneity: Multiparametric functional imaging to characterize variability and predict response following cervical cancer radiation therapy. Bowen SR, Yuh WTC, Hippe DS, Wu W, Partridge SC, Elias S, Jia G, Huang Z, Sandison GA, Nelson D, Knopp MV, Lo SS, Kinahan PE, Mayr NA. J Magn Reson Imaging. 2018 May;47(5):1388-1396. doi: 10.1002/jmri.25874. Epub 2017 Oct 16. PMID: 29044908

Functional lung avoidance and response-adaptive escalation (FLARE) RT: Multimodality plan dosimetry of a precision radiation oncology strategy.
Lee E, Zeng J, Miyaoka RS, Saini J, Kinahan PE, Sandison GA, Wong T, Vesselle HJ, Rengan R, Bowen SR. Med Phys. 2017 Jul;44(7):3418-3429. doi: 10.1002/mp.12308. Epub 2017 Jun 1. PMID: 28453861

Differential hepatic avoidance radiation therapy: Proof of concept in hepatocellular carcinoma patients. Bowen SR, Saini J, Chapman TR, Miyaoka RS, Kinahan PE, Sandison GA, Wong T, Vesselle HJ, Nyflot MJ, Apisarnthanarax S.Radiother Oncol. 2015 May;115(2):203-10. doi: 10.1016/j.radonc.2015.04.011. Epub 2015 Apr 28. PMID: 25934165

Spatially resolved regression analysis of pre-treatment FDG, FLT and Cu-ATSM PET from post-treatment FDG PET: an exploratory study.
Bowen SR, Chappell RJ, Bentzen SM, Deveau MA, Forrest LJ, Jeraj R. Radiother Oncol. 2012 Oct;105(1):41-8. doi: 10.1016/j.radonc.2012.05.002. Epub 2012 Jun 8. PMID: 22682748

On the sensitivity of IMRT dose optimization to the mathematical form of a biological imaging-based prescription function.
Bowen SR, Flynn RT, Bentzen SM, Jeraj R. Phys Med Biol. 2009 Mar 21;54(6):1483-501. doi: 10.1088/0031-9155/54/6/007. Epub 2009 Feb 13. PMID: 19218733

To see more of Dr. Bowen’s publications, please click here.

Research Interests

    Quantitative molecular imaging of cancer and normal tissue function for precision oncology

  • o Biological target and functional organ-at-risk definition for radiation therapy
  • o Biologically adaptive tumor dose escalation and functional tissue avoidance during radiation therapy planning
  • o Early treatment response assessment of multimodality cancer therapy (radiation therapy, chemotherapy, immunotherapy)
  • o Development of imaging biomarkers to complement tissue / peripheral biomarkers
  • o Radiomics and machine learning for response and outcome prediction