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Mark Groudine, M.D., Ph.D.

Professor

Overview

Dr. Groudine is the executive vice president and acting president and director of the Fred Hutchinson Cancer Research Center. He has published more than 200 papers in the course of his distinguished career. He is internationally recognized for his studies on the control of gene expression and on chromatin. His research team discovered mechanisms that orchestrate the structure of certain chromosomal regions and thereby silence or prevent the silencing of large sets of genes.

Patient Care Philosophy

Research is an important aspect of clinical care. Dr. Groudine is currently not seeing patients, instead devoting his time to research and advancing the knowledge base in cancer care.

Education and Training

College: University of Wisconsin, Madison, WA 1970

Medical Education: University of Pennsylvania, Philadelphia, PA, 1975

Graduate School: Cellular Differentiation Program, University of Pennsylvania, Philadelphia, PA 1976

Residency: Radiation Oncology, University of Washington, Seattle, WA, 1980

 

Fellowship:

  • Medical Scientist Training Program Fellowship, National Institutes of Health, 1976
  • European Molecular Biology Organization, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland 1973
  • Leukemia Society Special Fellowship, 1979
  • American Cancer Society Clinical Fellowship, 1980
  • Fellow, American Association for the Advancement of Science, 1994-2011
  • Fellow, American Academy of Arts and Sciences 2006

Memberships:

  • Member, National Academy of Sciences 2001-2003
  • Member, Institute of Medicine 2003 of the National Academy of Sciences 2003
  • Member, Founding Class of Washington State Academy of Sciences 2008.

Published Works

Rincon-Arano H, Parkhurst SM, Groudine M. (2013). UpSET-ing the balance: Modulating open chromatin features in metazoan genomes. FLY. 7:3, 1-8. Epub May 6, 2013.

Ritland Politz JC, Ragoczy T, Groudine M. When untethered, something inside comes. Nucleus 4(3) Epub ahead of print May 15 2013.

Klein BJ, Piao L, Xi Y, Rincon-Arano H, Rothbart SB, Peng D, Wen H, Larson C, Zhang X, Zheng X, Cortazar MA, Peña PV, Mangan A, Bentley DL, Strahl BD, Groudine M, Li W, Shi X, Kutateladze TG. The Histone-H3K4-Specific Demethylase KDM5B Binds to its Substrate and Product through Distinct PHD Fingers. Cell Rep. 2014 Jan 30. 6(2):325-335. Epub 2014 Jan 9.

Ali M*, Rincon-Arano H*, Zhao W, Rothbart SB, Tong Q, Parkhurst SM, Strahl BD, Deng L-W, Groudine M,** Kutateladze TG**. (2013). Molecular basis for chromatin binding and regulation of MLL5. Natl. Acad. Sci. USA 2013 Jun 24 [Epub ahead of print] (*co-first authors, **co-corresponding authors)

Gatchalian J, Futterer A, Rothbart SB, Ton Q, Rincon-Arano H, Sanchez-de-Diego A, Groudine M, Strahl D, Martinez-A C, van Wely KHM, Kutateladze TG. (2013). Dido3 PHD modulates cell differentiation and division. Cell Reports 2013 Jul 11;4(1):148-58. doi: 10.1016/j.celrep.2013.06.014. Epub Jul 3 2013.

Ritland Politz JC, Scalzo D, Groudine M. (2013). Something silent this way forms: The functional organization of the nuclear repressive compartment. Ann. Rev. Cell Dev. Biol. 29:241-270. Epub ahead of print July 5, 2013.

Skene PJ, Hernandez AE, Groudine M, Henikoff S. The nucleosomal barrier to promoter escape by RNA Polymerase II is overcome by the chromatin remodeler Chd1. Submitted 2014.