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Mark Groudine, M.D., Ph.D.

Professor

Overview

Dr. Groudine is the executive vice president and acting president and director of the Fred Hutchinson Cancer Research Center. He has published more than 200 papers in the course of his distinguished career. He is internationally recognized for his studies on the control of gene expression and on chromatin. His research team discovered mechanisms that orchestrate the structure of certain chromosomal regions and thereby silence or prevent the silencing of large sets of genes.

Patient Care Philosophy

Research is an important aspect of clinical care. Dr. Groudine is currently not seeing patients, instead devoting his time to research and advancing the knowledge base in cancer care.

Education and Training

College: University of Wisconsin, Madison, WA 1970

Medical Education: University of Pennsylvania, Philadelphia, PA, 1975

Graduate School: Cellular Differentiation Program, University of Pennsylvania, Philadelphia, PA 1976

Residency: Radiation Oncology, University of Washington, Seattle, WA, 1980

Fellowship:

  • Medical Scientist Training Program Fellowship, National Institutes of Health, 1976
  • European Molecular Biology Organization, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland 1973
  • Leukemia Society Special Fellowship, 1979
  • American Cancer Society Clinical Fellowship, 1980
  • Fellow, American Association for the Advancement of Science, 1994-2011
  • Fellow, American Academy of Arts and Sciences 2006

Memberships:

  • Member, National Academy of Sciences 2001-2003
  • Member, Institute of Medicine 2003 of the National Academy of Sciences 2003
  • Member, Founding Class of Washington State Academy of Sciences 2008.

Selected Publications from a Total of 308

Weintraub, H. and Groudine, M.: Chromosomal subunits in active genes have an altered conformation. Science 193, 848-856, 1976.

Bentley, D.L. and Groudine, M.: Control of c-myc transcription in HL60 cells by a block to elongation. Nature 321, 702-706, 1986.

Madisen, L. and Groudine, M.: Identification of a Locus Control Region (LCR) in the immunoglobulin heavy chain locus that deregulates c-myc expression in plasmacytoma and Burkitt’s Lymphoma cells. Genes & Development, 8, 2212-2226, 1994.

Sawado, T, Halow, J, Bender, M.A., and Groudine, M. The beta-globin locus control region (LCR) functions by enhancing the transition from transcription initiation to elongation. Genes and Development 17:1009-18, 2003. PMC196035

Schübeler D, Scalzo D, Kooperberg C, van Steensel, B, Delrow, J and Groudine M. Genome-wide DNA replication profile for Drosophila melanogaster: A link between transcription and replication timing. Nature Genetics. 32:438-442, 2002.

Schübeler D, MacAlpine D, Scalzo D, Wirbelauer C, Kooperberg C, van Leeuwe, F, Gottschling D, Turner B, Delrow J, Bell S, and Groudine, M. The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. Genes and Development 18: 1263-1271, 2004. PMC420352.

Rincon H, Halow J, Delrow J, Parkhurst SM, Groudine M. UpSET recruits HDAC complexes and restricts chromatin accessibility and histone acetylation at promoter regions. Cell 151:1214-1228, 2012.   PMC3518625.

Kosak ST, Scalzo D, Alworth SV, Li F, Palmer S, Enver T, Lee, JSJ, and Groudine, M. Coordinate Gene Regulation during Hematopoiesis is Related to Genomic Organization. PLoS Biology. 5:2602- 2613, 2007. PMC2080650

Rajapakse I, Perlman MD, Scalzo D, Kooperberg C, Groudine M and Kosak ST. The emergence of lineage-specific chromosomal topologies from coordinate gene regulation. Proc Natl Acad Sci (USA). 106:6679-84, 2009. PMC2654024

Verboon JM, Rincon H, Werwie TR, Delrow JJ, Scalzo D, Nandakumar V, Groudine M and Parkhurst SM. Wash interacts with lamin and affects global nuclear organization. Current Biology. 25(6):804-10, 2015. PMC4366290

To see more of Dr. Groudine’ s publications, please click here.

Research Interests

  • Gene expression, chromatin structure
  • Nuclear organization during pathogenesis