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Peter Goff, MD, PhD


Pete Goff, MD, PhD is a PGY5 resident in University of Washington’s Department of Radiation Oncology and an ABR Holman Research Pathway candidate. His research focus is on how DNA damage response inhibitors enhance the efficacy of radiotherapy and augment anti-tumor immunity in the laboratory of Dr. Paul Nghiem. He completed his MD, PhD (working with Dr. Peter Palese on antiviral immunity and oncolytic viruses), and medical internship at Mount Sinai Hospital in New York, NY. He enjoys Telemark skiing and goofing around with his daughter.


Education and Training

College: Middlebury College, Middlebury, VT; Biochemistry

Graduate School: Harvard University, Cambridge, MA; ALM Biology

Icahn School of Medicine at Mount Sinai, New York, NY; PhD Microbiology

Medical School: Icahn School of Medicine at Mount Sinai, New York, NY



Published works

Goff PH, Bhakuni R, Pulliam T, Lee JH, Hall ET, Nghiem P. Intersection of Two Checkpoints: Could Inhibiting the DNA Damage Response Checkpoint Rescue Immune Checkpoint-Refractory Cancer?. Cancers (Basel). 2021 Jul 8;13(14). doi: 10.3390/cancers13143415. Review. PubMed PMID: 34298632; PubMed Central PMCID: PMC8307089.

Goff PH, Schaub SK, Cook MM, Nghiem PN, Parvathaneni U. In Regard to Barker. Adv Radiat Oncol. 2021 May-Jun;6(3):100685. doi: 10.1016/j.adro.2021.100685. eCollection 2021 May-Jun. PubMed PMID: 34195497; PubMed Central PMCID: PMC8233461.

Goff PH, Zeng J, Rengan R, Schaub SK. Radiation and Modulation of the Tumor Immune Microenvironment in Non-Small Cell Lung Cancer. Semin Radiat Oncol. 2021 Apr;31(2):133-139. doi: 10.1016/j.semradonc.2020.11.010. Review. PubMed PMID: 33610270.

Wong PT, Goff PH, Sun RJ, Ruge MJ, Ermler ME, Sebring A, O’Konek JJ, Landers JJ, Janczak KW, Sun W, Baker JR Jr. Combined Intranasal Nanoemulsion and RIG-I Activating RNA Adjuvants Enhance Mucosal, Humoral, and Cellular Immunity to Influenza Virus. Mol Pharm. 2021 Feb 1;18(2):679-698. doi: 10.1021/acs.molpharmaceut.0c00315. Epub 2020 Jun 15. PubMed PMID: 32491861.

Cook MM, Schaub SK, Goff PH, Fu A, Park SY, Hippe DS, Liao JJ, Apisarnthanarax S, Bhatia S, Tseng YD, Nghiem PT, Parvathaneni U. Postoperative, Single-Fraction Radiation Therapy in Merkel Cell Carcinoma of the Head and Neck. Adv Radiat Oncol. 2020 Nov-Dec;5(6):1248-1254. doi: 10.1016/j.adro.2020.07.003. Epub 2020 Jul 21. PubMed PMID: 32838069; PubMed Central PMCID: PMC7373007.

Vijayakumar G, Palese P, Goff PH. Oncolytic Newcastle disease virus expressing a checkpoint inhibitor as a radioenhancing agent for murine melanoma. EBioMedicine. 2019 Nov;49:96-105. doi: 10.1016/j.ebiom.2019.10.032. Epub 2019 Oct 29. PubMed PMID: 31676387; PubMed Central PMCID: PMC6945240.

(2018). Martínez-Gil L, Goff PH, Tan GS. Chapter One – The Role of Self-Assembling Lipid Molecules in Vaccination. Advances in Biomembranes and Lipid Self-Assembly, Vol. 27. Elsevier. Eds. Iglič A, Rappolt M,  García-Sáez AJ.

(2017). Goff PH, Harrison LB, Furhang EE, Trichter F and Ennis RD. 2D kV orthogonal imaging with fiducial markers is more precise for daily image guided alignments than soft-tissue cone beam computed tomography for prostate radiation therapy. Advances in Radiation Oncology, May 4;2(3):420-428.

(2017). Goff PH, Hayashi T, He W, Yao S, Cottam HB, Tan GS, Crain B, Krammer F, Messer K, Pu M, Carson DA, Palese P, Corr M. Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice. Journal of Virology, 91(19).

(2015). US Patent 20,150,366,962: Synthetic TLR4 and TLR7 Ligands as Vaccine Adjuvants.  Carson DA, Cottam HB, Hayashi T, Corr T, Palese P, Goff P

(2015). Goff PH, Hayashi T, Martínez-Gil L, Corr M, Crain B, Yao S, Cottam HB, Chan M, Ramos I, Eggink D, Heshmati M, Krammer F, Messer K, Pu M, Fernandez-Sesma A, Palese P, Carson DA. Synthetic TLR4 and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained and broadly protective responses. Journal of Virology, 89(6): 3221-35.

(2014). Eggink D, Goff PH, and Palese P. Guiding the immune response against influenza virus hemagglutinin toward the conserved stalk domain by hyper-glycosylation of the globular head domain. Journal of Virology, 88(1): 699-704.

(2013). Goff PH, Eggink D, Seibert CW, Hai R, Martínez-Gil L, Krammer F, Palese P. Adjuvants and immunization strategies to induce influenza virus hemagglutinin stalk antibodies. PloS One, 8(11): e79194.

(2013). Martinez-Gil L, Almares-Sapuay JG, Ramana Reddy MV, Goff PH, Premkumar Reddy E, Palese P. A small molecule multi-kinase inhibitor reduces influenza A virus replication by restricting viral RNA synthesis. Antiviral Research, 100(1): 29-37.

(2013). Goff PH, Krammer F, Hai R, Seibert CW, Margine I, García-Sastre A, Palese P. Induction of cross-reactive antibodies to novel H7N9 influenza virus by recombinant Newcastle disease virus expressing a North American lineage H7 subtype hemagglutinin. Journal of Virology, 87(14): 8235-8240.

(2013). Seibert CW, Rahmat S, Krause JC, Eggink D, Albrecht RA, Goff PH, Krammer F, Duty JA, Bouvier NM, García- Sastre A, Palese P. Recombinant IgA is sufficient to prevent influenza virus transmission in guinea pigs. Journal of Virology, 87(14): 7793-7804.

(2013). Martínez-Gil L, Goff PH, Hai R, García-Sastre A, Shaw ML, Palese P. A Sendai virus-derived RNA agonist of RIG-I as a virus vaccine adjuvant. Journal of Virology, 87(3):1290-300.

(2012). Goff PH, Gao Q, Palese P. A majority of infectious Newcastle disease virus particles contain a single genome, while a minority contain multiple genomes. Journal of Virology, 86(19): 10852-6.

(2011). Logue EC, Taylor KT, Goff PH, Landau NR. The cargo-binding domain of transportin 3 is required for lentivirus nuclear import. Journal of Virology, 85(24): 12950-61.

(2011). Zha S, Jiang W, Fujiwara Y, Patel H, Goff PH, Brush JW, Dubois RL, Alt FW. Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions. Proc Natl Acad Sci U.S.A., 108(5): 2028-33.

(2011). Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature, 469(7329): 250-4.

(2010). Zha S, Bassing CH, Takaomi S, Brush JW, Patel H, Goff PH, Gatti R, Look AT, Alt FW. ATM-deficient thymic lymphoma is associated with aberrant TCR rearrangement. Journal of Experimental Medicine, 207(7): 1369-80.

(2009). Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature, 460(7252): 231-6.

(2009). Chakraborty T, Perlot T, Subrahmanyam R, Jani A, Goff PH, Zhang Y, Ivanova I, Alt FW, Sen R. A 220- nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation. Journal of Experimental Medicine, 206(5): 1019-27.

(2008). Li G, Alt FW, Cheng HL, Brush JW, Goff PH, Murphy MM, Franco S, Zhang Y, Zha S. Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Molecular Cell, 31(5):631-40.

(2007). Byers JH, Goff PH, Janson NJ, Mazzotta MG, Swigor JE. The Radical Addition of Dimethyl 2- Ethynylcyclopropane-1,1-dicarboxylate to Electron-Rich Olefins. Synthetic Communications, 37(11): 1865-1871.

Disclosed Awards/Honors:

2005 Honors in Chemistry and Biochemistry, Middlebury College
2014 Invited Speaker at Global Health and Emerging Pathogens Institute Seminar Series, Icahn School of Medicine at Mount Sinai
2015 Outstanding Teaching by a Graduate Student, Icahn School of Medicine at Mount Sinai
2019 Invited Speaker, Keystone Symposia Cancer Immunotherapy: Mechanistic Insights to Improve Clinical Benefit
2019 Housestaff Research Award, University of Washington
2020 Housestaff Research Award, University of Washington
2020-2021 RSNA Research & Education Foundation Resident Research Grant
2020-Present B. Leonard Holman Research Pathway, American Board of Radiology
2021 American Radium Society Annual Meeting Invited Speaker
2021 AACR/ASCO Methods in Clinical Cancer Research Workshop Participant