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Peter Goff, MD, PhD

Education and Training

College: Middlebury College, Middlebury, VT; Biochemistry

Graduate School: Icahn School of Medicine at Mount Sinai; PhD Microbiology

Harvard University, Cambridge, MA; ALM Biology

Medical School: Icahn School of Medicine at Mount Sinai; MD

 

Published works

(2018). Martínez-Gil L, Goff PH, Tan GS. Chapter One – The Role of Self-Assembling Lipid Molecules in Vaccination. Advances in Biomembranes and Lipid Self-Assembly, Vol. 27. Elsevier. Eds. Iglič A, Rappolt M,  García-Sáez AJ.

(2017). Goff PH, Harrison LB, Furhang EE, Trichter F and Ennis RD. 2D kV orthogonal imaging with fiducial markers is more precise for daily image guided alignments than soft-tissue cone beam computed tomography for prostate radiation therapy. Advances in Radiation Oncology, May 4;2(3):420-428.

(2017). Goff PH, Hayashi T, He W, Yao S, Cottam HB, Tan GS, Crain B, Krammer F, Messer K, Pu M, Carson DA, Palese P, Corr M. Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice. Journal of Virology, 91(19).

(2015). US Patent 20,150,366,962: Synthetic TLR4 and TLR7 Ligands as Vaccine Adjuvants.  Carson DA, Cottam HB, Hayashi T, Corr T, Palese P, Goff P

(2015). Goff PH, Hayashi T, Martínez-Gil L, Corr M, Crain B, Yao S, Cottam HB, Chan M, Ramos I, Eggink D, Heshmati M, Krammer F, Messer K, Pu M, Fernandez-Sesma A, Palese P, Carson DA. Synthetic TLR4 and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained and broadly protective responses. Journal of Virology, 89(6): 3221-35.

(2014). Eggink D, Goff PH, and Palese P. Guiding the immune response against influenza virus hemagglutinin toward the conserved stalk domain by hyper-glycosylation of the globular head domain. Journal of Virology, 88(1): 699-704.

(2013). Goff PH, Eggink D, Seibert CW, Hai R, Martínez-Gil L, Krammer F, Palese P. Adjuvants and immunization strategies to induce influenza virus hemagglutinin stalk antibodies. PloS One, 8(11): e79194.

(2013). Martinez-Gil L, Almares-Sapuay JG, Ramana Reddy MV, Goff PH, Premkumar Reddy E, Palese P. A small molecule multi-kinase inhibitor reduces influenza A virus replication by restricting viral RNA synthesis. Antiviral Research, 100(1): 29-37.

(2013). Goff PH, Krammer F, Hai R, Seibert CW, Margine I, García-Sastre A, Palese P. Induction of cross-reactive antibodies to novel H7N9 influenza virus by recombinant Newcastle disease virus expressing a North American lineage H7 subtype hemagglutinin. Journal of Virology, 87(14): 8235-8240.

(2013). Seibert CW, Rahmat S, Krause JC, Eggink D, Albrecht RA, Goff PH, Krammer F, Duty JA, Bouvier NM, García- Sastre A, Palese P. Recombinant IgA is sufficient to prevent influenza virus transmission in guinea pigs. Journal of Virology, 87(14): 7793-7804.

(2013). Martínez-Gil L, Goff PH, Hai R, García-Sastre A, Shaw ML, Palese P. A Sendai virus-derived RNA agonist of RIG-I as a virus vaccine adjuvant. Journal of Virology, 87(3):1290-300.

(2012). Goff PH, Gao Q, Palese P. A majority of infectious Newcastle disease virus particles contain a single genome, while a minority contain multiple genomes. Journal of Virology, 86(19): 10852-6.

(2011). Logue EC, Taylor KT, Goff PH, Landau NR. The cargo-binding domain of transportin 3 is required for lentivirus nuclear import. Journal of Virology, 85(24): 12950-61.

(2011). Zha S, Jiang W, Fujiwara Y, Patel H, Goff PH, Brush JW, Dubois RL, Alt FW. Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions. Proc Natl Acad Sci U.S.A., 108(5): 2028-33.

(2011). Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature, 469(7329): 250-4.

(2010). Zha S, Bassing CH, Takaomi S, Brush JW, Patel H, Goff PH, Gatti R, Look AT, Alt FW. ATM-deficient thymic lymphoma is associated with aberrant TCR rearrangement. Journal of Experimental Medicine, 207(7): 1369-80.

(2009). Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature, 460(7252): 231-6.

(2009). Chakraborty T, Perlot T, Subrahmanyam R, Jani A, Goff PH, Zhang Y, Ivanova I, Alt FW, Sen R. A 220- nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation. Journal of Experimental Medicine, 206(5): 1019-27.

(2008). Li G, Alt FW, Cheng HL, Brush JW, Goff PH, Murphy MM, Franco S, Zhang Y, Zha S. Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Molecular Cell, 31(5):631-40.

(2007). Byers JH, Goff PH, Janson NJ, Mazzotta MG, Swigor JE. The Radical Addition of Dimethyl 2- Ethynylcyclopropane-1,1-dicarboxylate to Electron-Rich Olefins. Synthetic Communications, 37(11): 1865-1871.